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The distance between the contour lines represents the steepness of the slope, the lesser the distance, the more is the steepness (changing pattern of interaction), while the larger space between contour lines represents a soft slope (lesser changing pattern) while no lines show flat region (constant type of interaction)

The student t-test was used for continuous variables and Chi-square test for categorical variables

Given that LC may be related to an abnormally regulated immune system various immunotherapy, including immunosuppressors and immunomodulators have been suggested for LC symptoms treatment ( The antiviral drug nirmatrelvir-ritonavir (Paxlovid) during acute infection decreased the incidence of LC (67)