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4.3 Study limitations This study provides a valuable reference for clinical practice, yet it is essential to recognize its inherent limitations

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Rotate injection sites (abdomen, thighs, upper arms) to help minimize irritation and tissue sensitivity

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Upon targeting efflux transporters, reprogramming cancer metabolism, inducing mitochondrial apoptosis, and synergizing with chemotherapeutic agents, berberine exhibits the multi-faceted nature of drug resistance

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