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Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E (2014) PI3K/AKT signaling pathway and cancer: an updated review

& Goumans, M

Conclusions In summary, our findings identified a novel regulatory mechanism for the oncogenic function of NF1 to regulate YAP stability through direct interaction between its PPQY motif and the WW domains of YAP1, even though NF1 was traditionally considered to be a tumor suppressor in RAS-MAPK signaling

thus, expert opinion suggests some level of safety in human subjects may be assumed

Acknowledgements This study was supported by the General Fund of Natural Science Foundation of Hunan Province (2023JJ30479), the Youth Fund of Natural Science Foundation of Hunan Province (2022JJ40330), the Scientific Research Project of the Health Commission of Hunan Province (202204014468), the Research Program of Hunan Administration of Traditional Chinese Medicine (D2022082), the Key Research Project of Hunan Health Commission (c202304019331) and the Outstanding Innovative Youth Training Program of Changsha (kq2306029)