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The fold change in target mRNA expression was determined using the 2 Ct method

114 There have been more than 200 mutations in the NLRP3 gene to be reported in association with CAPS in the INFEVER database

Ikezoe T, Yang Y, Saitoh T, et al

The assay revealed that the 312 highly responsive transcripts were dominated by the cyp-35s and ugts families with subsequent gene ontology analysis highlighting oxidationreduction processes (GO:0055114), transferase activity (GO:0016758), and response to xenobiotic stimulus (GO:0009410), among others

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MITOL-mediated HMOX2 ubiquitination facilitates the haem-degrading activity of HMOX2 K48-linked polyubiquitination is known as a signal for proteasomal degradation