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Patients using DSIP at night for sleep were shown to have improvements in their overall ability to cope with problems and emotions

Cases of OIH have been reported, both with short-term and longer-term use of opioid analgesics

(See Holford et al, 2013, for parameters in neonates and children.) Knowing the relationship between dose, drug concentration, and effects allows the clinician to take into account the various pathologic and physiologic features of a particular patient that make him or her different from the average individual in responding to a drug

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