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Indian J Surg (2023) 52:1128

Hardiman et al., 2017

There are many other possible causes of acanthosis nigricans, including: Addison's disease, a condition caused by a deficiency of hormones from the adrenal gland Disorders of the pituitary gland within the brain Growth hormone therapy Hypothyroidism (low levels of thyroid hormone caused by lowered activity of the thyroid gland) Oral contraceptives Polycystic ovary syndrome, a hormonal imbalance problem in people assigned female at birth Corticosteroid medications Autoimmune conditions like lupus and Sjogren's syndrome Most people with acanthosis nigricans have an insulin level that is higher than that of people of the same weight who don't have acanthosis nigricans

Analysis of the antioxidant response of Nicotiana benthamiana to infection with two strains of Pepper mild mottle virus

Abnormal glutathione transport in cystic fibrosis airway epithelia

Simultaneously, several meta-analyses and guideline panels highlight that many claimed indications are supported only by low- to moderate-quality evidence, with significant heterogeneity between trials and frequent failure of some strains or formulations to demonstrate superiority over placebo in rigorous, well-controlled studies (2, 3)