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These properties have led to the Food and Drug Administration (FDA) approval of several peptide-based therapeutics, some of which are summarized in Table 1 , while AMPs in various clinical phases are detailed in Table 2

[78] da Cunha MSB, Campos Hankins NA, Arruda SF

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221 PERK, the most studied UPR sensor, activates ATF4, resulting in widespread transcriptional activation of genes engaged in diverse pathways, including metabolism, autophagy, and cell death programs

7-Hydroxy-N,N-di-n-propyl-2-aminotetraline, a preferential dopamine D3 agonist, induces c-fos mRNA expression in the rat cerebellum

The publication bias disappeared after the exclusion of varicocele repair studies (p=0.6) (Fig