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Neurons, astrocytes, and oligodendrocytes all express it, and IGF-1 signaling has documented roles in neurogenesis, synaptogenesis, myelination, and neuronal survival

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Stem cell exhaustion and reduced regeneration NAD+ benefits become clear when we look at how its decline affects tissue repair

In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)