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Supplementary material The Supplementary Material for this article can be found online at: Glossary SARS severe acute respiratory syndrome MERS Middle East respiratory syndrome CRS cytokine release syndrome DIC diffuse intravascular coagulation MOF multiple organ failure ARDS abrupt respiratory distress syndrome Sepsis early recognition and optimized treatment DAMPs damage-associated patterns PAMPs pathogen-associated patterns Tfh cell T follicular helper cell IFN- interferon-gamma MCP-1 monocyte chemoattractant protein-1 MIP-1 macrophage inflammatory protein-1 IL-6 interleukin-6 IP-10 interferon-induced protein-10 TNF- tumor necrosis factor alfa MAS macrophage activation syndrome ACE-2 angiotensin-converting enzyme-2 TAK Janus kinase COPD chronic obstructive pulmonary disease ATRA all trans-retinoic acid MIS-C multisystem inflammatory syndrome in children S-CSS associated cytokine storm syndrome NLRP-3 NLR-family pyrin domain containing 3 RBD receptor binding domain IAVG Independent Allocation of Vaccines Group RAAS reninangiotensinaldosterone system G-CSF granulocyte colony-stimulating factor GM-CSF granulocytemacrophage colony-stimulating factor M-CSF macrophage colony-stimulating factor HGF hepatocyte growth factor CXCL-8 C-X-C motif chemokine ligand 8 ICU intensive care unit RA rheumatoid arthritis GVHD graft- versus -host disease ICPI intracerebral pathogenicity index References 1 AhmadJ.KhanI.BlundellR.AzzopardiJ.MahomoodallyM

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It helps to enhance immune cell function and regulate immune responses