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However, fat cells that expire in the area above the circ scar line sometimes get trapped and cant easily reabsorb and turn into palpable nodules known as fat necrosis (dead fat cells).

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and to M.J.v.G.), an AMC Fellowship from Amsterdam UMC (M.J.v.G.), Vici grant from the Netherlands Organization for Scientific Research (NWO) (R.W.S), a Vidi and Aspasia grant from the NWO (grant numbers 91719372 and 015.015.042) (J.S.), the Bill & Melinda Gates Foundation (OPP1156262 to N.P.K

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Abbreviations BMP: bone morphogenetic protein CMap: Connectivity Map COPD: chronic obstructive pulmonary disease CT: computed tomography DLCO: diffusing capacity of carbon monoxide DMEM: Dulbecco's modified Eagle's medium ECM: extracellular matrix FBS: fetal bovine serum FDR: false discovery rate FEV 1 : forced expiratory volume in 1 second FVC: forced vital capacity GOLD: Global Initiative for Chronic Obstructive Lung Disease GSEA: Gene Set Enrichment Analysis Lm: mean linear intercept PBS: phosphate-buffered saline TGF: transforming growth factor Vv: volume fraction