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doi: 10.22270/jddt.v13i4.5781 217

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The ablation of FASN in a mouse model and in vitro livers did not affect AKT/NCID-induced iCCA formation, and CCA cells with low expression levels of FASN tended to have high expression levels of FA uptake-associated proteins and robust FA uptake capacity [36, 37]

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This evidence supports a multi target therapeutic paradigm that is consistent with the multifactorial nature of ASD and suggests that combined interventions, for example, omega3 with vitamin D or vitamin E, or cysteine rich proteins to boost glutathione, may exert additive or synergistic effects across redox, mitochondrial, and immune pathways (Politi et al., 2008