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After the recovery of cellular redox homeostasis, KEAP1 translocates into the nucleus through Karyopherin 6 (importin 7), inducing NRF2 nuclear export to the cytosol, in a CRM1-dependent process through Nuclear Export Signal (NES) sequences present in NRF2

Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter

doi: 10.1016/j.jsbmb.2018.09.021 [DOI] [PubMed] [Google Scholar] 14.Ramadori GP

This means the action can be so specific to the molecular level

MTHFR and COMT mutations can reduce methylation activity and result in the accumulation of harmful estrogens