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At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling (178180)

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Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer

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The number was the lowest compared with the GPx1 mutant (28%) and the GPx4 mutant (40%) produced in our previous work 15,16