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While the research is still relatively small, this supplement may be especially useful for people who feel overstimulated, mentally fried, or physically overtrained

Excess copper is reduced by FDX1 to generate Cu, which drives cell death via two primary mechanisms: (1) Cu-mediated aggregation of lipoylated TCA cycle proteins (e.g., DLAT) and loss of Fe-S clusters, and (2) Cu-induced disruption of the Npl4/p97 protein quality-control system

A randomized trial of vitamin E supplementation and cognitive function in women

Science 241, 462464

(2020) reported that irisin activates the Nrf2 pathway, which is known to regulate proteasomal function and oxidative stress responses, potentially contributing to reduced protein aggregation 33

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