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The first interface is between the CBS-2 and CBS-1 motifs, involving loop 516525 of one dimeric subunit and -helix 15 of the neighbouring dimeric subunit

These are mechanistic findings from peer-reviewed literature

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This environment induces the dedifferentiation of vascular smooth muscle cells (VSMCs) from a contractile phenotype to an activated, secretory and migratory phenotype

Initially monoclonal antibodies (mAB) targeting IGF-1R such as dalotuzumab (MK-0646), ganitumab (AMG479), cixutumumab (IMC-A12), and figitumumab (CP-751871) were investigated

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