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Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

(Preprint) bioRxiv (2023)

While this mechanism is theoretically plausible, the role of HO-1 in different cell types and microenvironments remains controversial, as experimental findings are sometimes inconsistent ( In conclusion, HO-1 holds significant potential as a therapeutic target for atherosclerosis, but its clinical application faces many challenges

Li, Q., Zhou, T., Wu, F., Li, N., Wang, R., Zhao, Q., & Ma, B

4 Mitochondrial dysfunction and energy metabolism imbalance As the largest avascular tissue in the human body, IVD has energy metabolic characteristics closely associated with degeneration