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5) with an incorporated boron difluoride complex in the center of the polymethine chain 179

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In short, disulfide bond linkers keep conjugates intact during systemic circulation, and are selectively cleaved by the high intracellular concentration of glutathione, releasing the active drugs at the tumor sites from the non-toxic prodrugs

10.1002/hep.29183 68 LiuP.LuD.Al-AmeriA.WeiX.LingS.LiJ.et al (2020)

If these units are not available and the primary care team has no experience with the management of these patients, they will need to be referred to an emergency department to receive the parenteral treatment

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