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doi: 10.1186/gb-2012-13-9-r79 31 AtarashiKTanoueTShimaTImaokaAKuwaharaTMomoseYet al

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As gut-brain connectivity is bi-directional, it is plausible that PD pathologies might also spread from the CNS into the gut

They are also important for the biosynthesis of short-chain fatty acids

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Ferulic acid was shown to reduce weight gain and correct the HFD-induced gut microbiota imbalance, and significantly promoted the accumulation and receptor expression of short-chain fatty acid-producing bacteria in the intestine, including Olsenella, Eisenbergiella, Dubosiella, Clostridiales_unclassified , and Faecalibaculum , reduced endotoxigenic or obesity-associated bacteria, decreased LPS, and inhibited the colonic TLR4/NF-B pathway