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Advancing FDA-approved excipients with enzymatically cleavable coatings, innovating adaptable charge-reversal mechanisms responsive to heterogeneous tumour microenvironments, and exploring alternative activation modalities beyond photoresponsive systems will accelerate clinical translation and broaden applications beyond oncology to include retinal therapy, inflammatory diseases, and mRNA vaccine delivery, heralding a new era of personalized, multimodal, and highly effective therapies driven by the next generation of charge-reversible nanocarriers

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Kim HJ, Lee Y, Fang S, Kim W, Kim HJ, Kim JW (2020) GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress

The ultimate aim of any experimental system should be replication of human pathophysiology which is central to translate findings to the clinic

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