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10.1038/cddiscovery.2016.89 Cell Death Discov

Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways

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Meanwhile, GPX1 overexpression constrained oxidative stress and apoptosis in OA chondrocytes by regulating CREB/HO-1 [149]

In severe cases of uremic toxicity related to p-cresol or para-cresol sulfates, synbiotics can promote the growth of Bifidobacterium bifidum strains and increase Lactobacillus abundance in the gut

The acyl-coenzyme A (CoA) synthetase long-chain family (ACSL) located on the mitochondrial outer membrane and endoplasmic reticulum (ER) can catalyze the transformation of fatty acids to acyl-CoAs ( Studies conducted on the haploid cell line KBM7 through insertional mutagenesis indicate that the inactivation of LPCAT3 and ACSL4 allows cells to become resilient against RSL3 and ML162, two GPX4 inhibitors ( - ) and GPX4 are effective suppressors of ferroptosis, while ACSL4 and LPCAT3 are identified as pro-ferroptosis due to their role in incorporating PUFAs into membrane lipids