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Neuropsychobiol 55:112120 Van Oosterwijck J, Nijs J, Meeus M et al (2010) Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study

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Chronic exposure to high levels of cortisol can lead to a reduction in dopamine synthesis and receptor sensitivity, particularly in the mesolimbic pathway, which is associated with reward processing and motivation

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