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These osmolytes are obtained from food and synthesized endogenously using dietary constituents like choline and carnitine

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Nov 2022;32(11):2493-2504

5.3 The gut barriersystemic inflammation axis: a common convergence endpoint and mechanistic landing point across modules 5.3.1 Module positioning: why it serves as a common endpoint For the functional outputs of different metabolic modules to influence synovial inflammation and structural damage, they likely traverse a common conduit: Gut Barrier Permeability AlterationSystemic Inflammation AmplificationPeripheral Immune Activation. (Liu et al., 2018)

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