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Table 15

Some studies indicate people with obesity have low vitamin B12 levels

Most patients feel the energy lift within 24 to 48 hours

Am J Trop Med Hyg 80: 737738

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern