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Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

The study was conducted in a mouse model with BRAF and NRAS mutations, as well as wild-type melanoma xenografts and allografts of highly metastatic melanoma (222)

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The results revealed that similar patterns of metabolic pathways were observed among the seven experimental groups of mice with EIF, showing that a total of 44 KEGG pathways were enriched in a total of six categories of KEGG database, including human diseases, organismal systems, environmental information processing, cellular process, metabolism, and genetic information processing (Figure 5