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To date, the term bio-corona has been introduced as an alternative to protein corona to more accurately represent the complex array of biomolecular components present in biological fluids to which nanoparticles are exposed ( in vivo biological properties of nanoparticles remains a major challenge for the rational design of nanomaterials for clinical applications

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In some embodiments, agents and compositions encompassed by the present invention are hydrophobic and can form kinetically stable complexes with gold nanoparticles functionalized with water-soluble zwitterionic ligands (see, e.g., Kim et al (2009) JACS 131: 1360-

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