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Taken together with the findings of routine histopathologic examination and IHC, this genomic profile, with mutation in PRKAR1A only and monosomies of multiple chromosomes, including 1, 2, and 17, was diagnostic for MMNSTs

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Therefore, pre-operative mapping of MIS margins serve as the necessary tool for conservative curative surgery in larger melanoma in situ lesions or in those with poorly defined borders