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Drareni K, Ballaire R, Barilla S, Mathew MJ, Toubal A, Fan R, et al

S-nitrosylations are post-translational modifications (PTM) that originate from the reaction between the messenger nitric oxide (NO) and a thiol group in a cysteine residue

Acta Pharmacol Sin 40(6):814822 Cheng T, Sudderth J, Yang C et al (2011) Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

So, for example, 8M urea or 6M guanidine HCl would likely denature GST, preventing the GST-glutathione interaction that serves as the foundation for this purification

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But again, set expectations: body skin is thicker, contact time is the same or less, and lifestyle/sun exposure may affect results