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For example, GPx1 has been reported to prevent oxidative DNA mutations, which in turn may prevent the development of tumors [42], and research shows that overexpression of GPx1 can reduce tumor growth, indicating its inhibitory effect in tumorigenesis [43]

As a model for physiological conditions the cancer cells were cultivated and treated with a 21% O 2 atmosphere, and as a model for hypoxic conditions the cancer cells were cultivated and treated with a 1% O 2 atmosphere

for example, N -acetylcysteine (NAC) in preadipocytes reduces adipogenesis [27]

3, Supplementary Figs

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Statistical analysis All experiments were performed independently at least three times and the data were shown as mean and S.E.M