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The process begins with a hydroxyl radical attacking specific bis-allylic positions in the fatty acid side chains, generating an alkyl radical (Yadav et al., 2019)

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The UPRmt preserves mitochondrial import to extend lifespan

Although the mechanisms by which ET enhances ERAD remain under investigation, our results in Figures 5 and 6 point to effects of inhibiting -oxidationand by extension promoting glutathione oxidationon ER protein oxidative maturation and quality control