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Dense extracellular matrices, abnormal vasculature, and high interstitial fluid pressures significantly restrict nanoparticle distribution, especially in hypoxic tumor cores where immune activation is most needed

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Physiological and pharmacological influences on thyroxine to 3,5,3-triiodothyronine conversion and nuclear 3,5,3-triiodthyroidne binding in rat anterior pituitary

The resulting paracrine mediators, including extracellular cGAMP and NK cell chemokines, promote macrophage M1 polarization and facilitate NK cell recruitment (Fig