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Cell culture Human malignant melanoma (A375) cells were obtained from the American Type Culture Collection (ATCC, CRL-1619IG-2) and used within ten passages for all experiments

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Suppression of pro-inflammatory cytokines (TNF-

How it works: Kisspeptin-10 stimulates part of the brain to release gonadotropin-releasing hormone (GnRH), the hormone that triggers the release of two key hormones that control ovulation and testosterone production

NF-B, nuclear factor kappa B