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1 Introduction Migraine, a disorder influenced by genetics and characterized by multiple factors involving neurological, glial, and vascular systems, ranks as the second most debilitating condition worldwide, impacting the health of over one billion individuals globally (1)

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Interestingly, they found that self-reported depressive symptoms were positively associated with fecal acetate concentrations and negatively associated with butyrate and propionate levels [205]

Figure 1 SFN does not impair T-cell/APC conjugate and immune synapse formation To evaluate the effects of SFN on T-cell activation, we analyzed early and late activation events

TABLE 2 Core pharmacological mechanisms of glycyrrhizic acid in the Liver