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However, during aging, the interaction between fibroblasts and the ECM is disrupted by the fragmentation of collagen fibers

Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, et al

For example, RSV infection induces vagus nerve activation, with potential anterograde transport along the olfactory nerve into the CNS, triggering neural remodeling and suggesting that pathogen transmission from the lung to the brain occurs via specific cranial nerve pathways potentially linked to CNS injury [328,329,330]

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C u = the unbound IGF-I with the presence of IGFBP-3