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Researchers have also extensively investigated the potential of PLGA NPs as effective DDSs in managing IOP in glaucoma patients

Current preclinical and lab research is exploring its effects beyond fat metabolism

The hyperstimulated NMDA receptor causes excessive Ca influx and subsequent rapid, sustained phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) [69]

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Indeed, tumor cells can release interleukins (IL-6 and IL-1), TNF-, interferon gamma (IFN-), zinc-2-glycoprotein (ZAG), or parathyroid hormone-related protein (PTHrP), which can promote adipocyte browning and lipolysis [82-85]

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