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It phosphorylates upstream stimulatory factor 1 (USF1) and then upregulate fatty acid synthase (FASN), which promotes de novo lipogenesis (DNL) in liver and aggravates hepatic fat deposition

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doi: 10.1016/j.cmet.2007.05.002 124 SuXKongYPengD

Evaluation of Glutathione S-transferase T1 (GSTT1) deletion polymorphism on type 2 diabetes mellitus risk in a sample of Yazdian females in Yazd, Iran

doi: 10.1073/pnas.1603244113 166 YangL.ZhouY.JiaH.QiY.TuS.ShaoA

Therefore, cattle (and other ruminants) that become B12-deficient, regardless of how theyre raised, arent just B12-deficient because their rumens arent synthesizing enough vitamin B12