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Sequence analysis had identified an amino acid motif GDD play an essential role for polymerase activity [59]

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Effects of Low Oxygen Concentrations and Metabolic Inhibitors on Proteoglycan and Protein Synthesis Rates in the Intervertebral Disc

The more hypoxic the cell, the more glycolysis is used leading to production of pyruvate

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10.1007/s12015-023-10549-7 366 WangL.WangL.WangR.XuT.WangJ.CuiZ.et al (2024a)