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Knockdown (KD) of ERK1/2 by siRNA attenuated TGF 2 -induced downregulation of CPT1A and upregulation of fibrosis markers (CTGF and fibronectin) (Fig

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CTCF, a CCCTC-binding factor, is a known transcriptional suppressor of c-Myc, but its inhibitory effect is reduced after phosphorylation [41, 42], possibly because of the fact that phosphorylation of CTCF reduces its DNA-binding activity [43]

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ABCD1 deficiency can induce the spontaneous production of ROS in low doses or even in the absence of VLCFA