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[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration

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(In simpler terms, scientists could rearrange the amino acids within the peptide to make the molecule more effective at activating target receptors.) Eventually, new analogs were synthesized that had both in vitro and in vivo activity [5]

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However, the tubules formed by the SNX1-SNX2a complex were more distorted than those formed by SNX1 alone, as revealed by negative-stain TEM (Fig

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