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EsfandiariAPourghassem GargariBNoshadHSarbakhshPMobasseriMBarzegariMet al

An estimated 3-12% of people treated with opioids for chronic pain will develop an addiction or abuse with negative consequences.(12) Approximately 8.6 million Americans reported misusing prescription opioids in 2023.(13) People who develop tolerance or dependence to prescription opioids may transition to illegally produced opioids, such as a fentanyl

Cell viability was assessed 3 days after treatment with FOXO4-DRI at 0, 12.5, 25, 50, and 100 M, respectively, using the Cell Counting Kit-8 (CCK-8) Assay (Dojindo, Rockville, MD, United States)

These products, including topical creams, joint supplements, ergonomic supports, and heating or cooling pads, aim to enhance joint health and promote comfort