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Its mechanism of action is, at least partially, associated with the attenuation of oxidative stress and enhancement of immune function

Toosendanin reduces cisplatin resistance in ovarian cancer through modulating the miR-195/ERK/-catenin pathway

The anti-ferroptotic ability of these ion chelators has been largely explored across many conditions, including intestinal cell injury (37), traumatic spinal cord injury (92), osteoarthritis (93), type 2 diabetic osteoporosis (94), atherosclerosis (95), neuroprotection (96) and acute lung injury (97)

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However, in a randomized trial of 99 patients, silymarin supplementation (700 mg, given three times daily for 48 weeks) did not reduce NAS by 30% or more in a significantly higher proportion of patients with MASH compared to placebo [198]