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106-108 Most medications used to treat UC have excellent safety data in pregnancy and breastfeeding, except for methotrexate, JAK inhibitors and sphingosine 1-phosphate receptor modulators

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Although the pathophysiology of endometriosis is not fully explained, retrograde menstruation is the most common theory, and endometriotic cells are known to have a high migratory capacity, be resistant to apoptosis and induce inflammation 3,5,8,9,10,11

Subsidizing R&D costs through the governments push-and-pull incentives may facilitate renewing the innovation for antibiotics

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The sponsor has no any influence on designing the study