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As before, we represent the resting state of the enzyme as Enz-[Por-Fe(III)], and the active state oxo-ferryl Compound 1 as Enz-[Por+.-Fe(IV)=O]

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Cells were treated with 40100 M KL1 or 110 M BIX-01294 in the presence of 50 g ml 1 Gen in 5 replicates for 48 h

In addition to these pivotal genes, more than 100 genes have been implicated in the pathogenesis of RA, including genes from the tumour necrosis factor and interleukin families, as well as the osteopontin family (Fig