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Under nutrient-replete conditions, the deacetylation of malonyl CoA decarboxylase (MCD) by SIRT4 plays a pivotal role in lipid homeostasis via suppressing fatty acid oxidation and inducing lipid anabolism

After SCI, PGC-1 expression decreases (110), and expression of myosin heavy chain protein also decreases accordingly ( 3 associated with muscle atrophy and mass loss (110)whose expression is increased after SCI, indirectly causing the expression of Atrogin-1 and MuRF1, resulting in muscle atrophy (113)

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IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor

Corticosteroid injections provide short-term relief but may not improve long-term outcomes and could potentially weaken the tendon with repeated use

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