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doi: 10.1038/s41419-024-06842-z 99 FuJZhangPSunZLuGCaoQChenYet al

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Before starting B12 supplements , particularly high-dose formulations, discuss with your GP if you have: A history of sleep disorders Existing anxiety or mood disorders Cardiovascular conditions Kidney disease (which may affect B12 metabolism and test interpretation) Leber's hereditary optic neuropathy (cyanocobalamin is contraindicated