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At the LOQ level, the aim was to attain a concentration of 1.4250 g/mL

The activity of BAX and BAK1 is contingent upon their activation, which is facilitated by a second class of pro-apoptotic BCL-2 family proteins, the BH3-only proteins such as Bcl-2 interacting mediator of cell death (BIM) and BH3 interacting-domain death agonist (BID) 1,2

Disease can lower glutathione through inflammation, oxidative reactions, impaired synthesis, altered nutrient status, tissue damage or medication effects

Han, D., Guan, X., Zhu, F., Yang, Q

Dechallenge: Improvement in liver tests is usually observed within a few days (acetaminophen) or few weeks (macrolide antibiotics or sulfonamides) of discontinuation of the offending agent

A portion of the tissue (~15 mg) was inserted into a zirconium oxide (ZrO 2 ) 4 mm outer diameter rotor using an insert to make a spherical sample volume of 25 L