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422 In recent years, the mechanisms by which cancer cells develop resistance to various treatment methods have been gradually revealed, and it has been comprehensively summarized in several reviews

doi: 10.1038/s41565-020-00810-2 70 KellyBONeillLAJ

doi: 10.3389/fbioe.2019.00032 80 HanssensL

This multiprotein complex activates executioner caspases, such as caspase-3, initiating a cascade of proteolytic events that ultimately lead to the programmed death and clearance of damaged neurons (106)