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However, the etiologies of radiation-induced cataracts and age-related cataracts differ, they share similarities in histopathological changes in the lens, such as increased epithelial cell apoptosis, liquefaction of lens fiber cells, and aggravated oxidative stress responses ( In summary, as a new development in cell death, ferroptosis provides a new research direction for understanding the pathogenesis of radiation-induced cataracts

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Research from the STEP 1 trial showed that nausea affected 44.2% of participants on the 2.4 mg maintenance dose, compared to 17.4% on placebo