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The analysis found low doses were as effective as full doses for preventing recurrent VTEs, but low-dose DOAC therapy reduced the risks of major and clinically relevant non-major bleeding events compared with full-dose therapy, with no significant differences between apixaban and rivaroxaban

1 China is one of the countries with the fastest aging rates in the world, and the proportion of people aged 60 and above is expected to reach 28% by 2040

Jhaveri A, Deshpande P, Pattni B, Torchilin V

The changes in glutamate-gated chloride channel subunits, the enhanced expression of efflux transporters, and the changes in parasite metabolism have been identified as the probable contributors to decreased susceptibility to drugs in experimental and field studies (120126)

Gastrointestinal Disorders: Conditions like Crohn's disease, celiac disease, or a history of weight-loss surgery (like gastric bypass) can damage the exact parts of the intestine that are in charge of B12 absorption

Dvl2: Dishevelled-2