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Research protocols typically use daily dosing for 714 days during the induction phase, with therapeutic effects lasting 30+ days post-treatment despite complete plasma clearance within 12 hours of the final dose

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Despite these advances, CAR-M research in AIDs remains largely preclinical, underscoring the need for clinical safety validation, and systemic CAR-M distribution, notably hepatic accumulation, poses risks of off-target toxicity and reduced efficacy (108)

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Hiddemann, W, Andreeff M , Clarkson BD

Icaritin was also reported to decrease intratumoral and splenic MDSCs, which are immunosuppressive cells dampening T cell cytotoxicity