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Cationic systems like polyplex systems can escape from the endosomes/lysosomes because they have the ability to buffer pH and cause osmotic swelling of these organelles according to the so-called "proton sponge-mediated escape" theory

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Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoforms

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In the treatment of IBD, therapeutic peptides are predominantly small molecules, typically comprising 210 amino acids, with 38 residues being most commona length that likely facilitates intestinal transport via peptide transporters while minimizing enzymatic degradation